Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection.

ABSTRACT:

Background

Influenza virus infections are a major public health concern worldwide. Conventional treatments against the disease are designed to target viral proteins. However, the emergence of viral variants carrying drug-resistant mutations can outpace the development of pathogen-targeting antivirals. Diphyllin and bafilomycin are potent vacuolar ATPase (V-ATPase) inhibitors previously shown to have broad-spectrum antiviral activity. However, their poor water solubility and potential off-target effect limit their clinical application.

Methods

In this study, we report that nanoparticle encapsulation of diphyllin and bafilomycin improves the drugs' anti-influenza applicability.

Results

Using PEG-PLGA diblock copolymers, sub-200 nm diphyllin and bafilomycin nanoparticles

SUBMITTER: Hu CJ 

PROVIDER: S-EPMC6298390 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature