A novel multichoice touchscreen paradigm for assessing cognitive flexibility in mice.

ABSTRACT: Cognitive flexibility refers to various processes which enable behaviors to be modified on the basis of a change in the contingencies between stimuli or responses and their associated outcomes. Reversal learning is a form of cognitive flexibility which measures the ability to adjust responding based on a switch in the stimulus-outcome contingencies of, typically two, perceptually distinct stimuli. Reversal tasks have provided valuable insight into the neural basis of cognitive flexibility, implicating brain regions including the lateral orbitofrontal cortex (lOFC) and dorsomedial prefrontal cortex (dmPFC). However, with two-stimulus reversal, it is difficult to determine whether response errors are due excessive perseveration, deficient learning, or other problems with updating. To address

SUBMITTER: Piantadosi PT 

PROVIDER: S-EPMC6298539 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature