Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts.

ABSTRACT:

Background & aims

Most patients with esophageal adenocarcinoma (EAC) present with de novo tumors. Although this could be due to inadequate screening strategies, the precise reason for this observation is not clear. We compared survival of patients with prevalent EAC with and without synchronous Barrett esophagus (BE) with intestinal metaplasia (IM) at the time of EAC diagnosis.

Methods

Clinical data were studied using Cox proportional hazards regression to evaluate the effect of synchronous BE-IM on EAC survival independent of age, sex, TNM stage, and tumor location. We analyzed data from a cohort of patients with EAC from the Mayo Clinic (n=411; 203 with BE and IM) and a multicenter cohort from the United Kingdom (n=1417; 638 with BE and IM).

Results

In the Mayo coho

SUBMITTER: Sawas T 

PROVIDER: S-EPMC6298575 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature