Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI.

ABSTRACT: Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extravascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations, and tumor xenograft models to investigate the technical feasibility of convection-MRI. We observed a significant correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive

SUBMITTER: Walker-Samuel S 

PROVIDER: S-EPMC6298581 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature