Lifelong memory responses perpetuate humoral T_H2 immunity and anaphylaxis in food allergy.

ABSTRACT:

Background

A number of food allergies (eg, fish, shellfish, and nuts) are lifelong, without any disease-transforming therapies, and unclear in their underlying immunology. Clinical manifestations of food allergy are largely mediated by IgE. Although persistent IgE titers have been attributed conventionally to long-lived IgE⁺ plasma cells (PCs), this has not been directly and comprehensively tested.

Objective

We sought to evaluate mechanisms underlying persistent IgE and allergic responses to food allergens.

Methods

We used a model of peanut allergy and anaphylaxis, various knockout mice, adoptive transfer experiments, and in vitro assays to identify mechanisms underlying persistent IgE humoral immunity over almost the entire lifespan of the mouse (18-20 mon

SUBMITTER: Jimenez-Saiz R 

PROVIDER: S-EPMC6298600 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature