Odor-evoked category reactivation in human ventromedial prefrontal cortex during sleep promotes memory consolidation.

ABSTRACT: Slow-wave sleep is an optimal opportunity for memory consolidation: when encoding occurs in the presence of a sensory cue, delivery of that cue during sleep enhances retrieval of associated memories. Recent studies suggest that cues might promote consolidation by inducing neural reinstatement of cue-associated content during sleep, but direct evidence for such mechanisms is scant, and the relevant brain areas supporting these processes are poorly understood. Here, we address these gaps by combining a novel olfactory cueing paradigm with an object-location memory task and simultaneous EEG-fMRI recording in human subjects. Using pattern analysis of fMRI ensemble activity, we find that presentation of odor cues during sleep promotes reactivation of category-level information in ventromedial p

SUBMITTER: Shanahan LK 

PROVIDER: S-EPMC6298770 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature