Ontology highlight
ABSTRACT:
SUBMITTER: Sawen P
PROVIDER: S-EPMC6298771 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
eLife 20181218
A hallmark of adult hematopoiesis is the continuous replacement of blood cells with limited lifespans. While active hematopoietic stem cell (HSC) contribution to multilineage hematopoiesis is the foundation of clinical HSC transplantation, recent reports have questioned the physiological contribution of HSCs to normal/steady-state adult hematopoiesis. Here, we use inducible lineage tracing from genetically marked adult HSCs and reveal robust HSC-derived multilineage hematopoiesis. This commences ...[more]