Mild renal impairment is associated with calcified plaque parameters assessed by computed tomography angiography in people living with HIV.

ABSTRACT:

Objective

To investigate the association of mild renal impairment and coronary plaque in people living with HIV (PLHIV).

Methods

PLHIV and non-HIV controls with serum creatinine less than 1.5 mg/dl were investigated. Estimated glomerular filtration rate (eGFR) (calculated by CKD-EPI formula) was related to coronary plaque indices obtained by CT angiography.

Results

One hundred and eighty-four PLHIV [HIV viral load, 49 (47,49) copies/ml, CD4+ cell count, median 536 (370, 770) cells/μl, duration HIV, 15 ± 7 years] and 72 HIV-negative controls without known cardiovascular disease (CVD) were studied. The two groups were well matched for traditional CVD risk factors. Serum creatinine (0.9 ± 0.2 vs. 0.9 ± 0.2 mg/dl, P = 0.96) and eGFR (96 ± 22 vs. 96 ± 24 ml/min per 1.73 m(

SUBMITTER: Cheru LT 

PROVIDER: S-EPMC6298826 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature