IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice.

ABSTRACT:

Background

Serum IL-22 levels are increased in patients with atopic dermatitis, which commonly precedes asthma in the atopic march. Epicutaneous sensitization in mice results in T_H2-dominated skin inflammation that mimics atopic dermatitis and sensitizes the airways for antigen challenge-induced allergic inflammation characterized by the presence of both eosinophils and neutrophils. Epicutaneous sensitization results in increased serum levels of IL-22.

Objective

We sought to determine the role of IL-22 in antigen-driven airway allergic inflammation after inhalation challenge in epicutaneously sensitized mice.

Methods

Wild-type (WT) and Il22^-/- mice were sensitized epicutaneously or immunized intraperitoneally with ovalbumin (OVA) and challenged i

SUBMITTER: Leyva-Castillo JM 

PROVIDER: S-EPMC6298864 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature