Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach.

ABSTRACT:

Objective

Precision medicine drug therapy seeks to maximize efficacy and minimize harm for individual patients. This will be difficult if drug response and side effects are positively associated, meaning that patients likely to respond best are at increased risk of side effects. We applied joint longitudinal-survival models to evaluate associations between drug response (longitudinal outcome) and the risk of side effects (survival outcome) for patients initiating type 2 diabetes therapy.

Study design and setting

Participants were randomized to metformin (MFN), sulfonylurea (SU), or thiazolidinedione (TZD) therapy in the A Diabetes Outcome Progression Trial (ADOPT) drug efficacy trial (n=4,351). Joint models were parameterized for 1) current HbA1c response (change from baseli

SUBMITTER: Dennis JM 

PROVIDER: S-EPMC6298877 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature