Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber.

ABSTRACT: Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system^1-4. Advances in wavefront-shaping methods and computational power have recently allowed for a novel approach to high-resolution imaging, utilizing deterministic light propagation through optically complex media and, of particular importance for this work, multimode optical fibers (MMFs)^5-7. We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications. The volume of tissue lesion was reduced by more than 100-fold, while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation thr

SUBMITTER: Vasquez-Lopez SA 

PROVIDER: S-EPMC6298975 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature