Characterizing early drug resistance-related events using geometric ensembles from HIV protease dynamics.

ABSTRACT: The use of antiretrovirals (ARVs) has drastically improved the life quality and expectancy of HIV patients since their introduction in health care. Several millions are still afflicted worldwide by HIV and ARV resistance is a constant concern for both healthcare practitioners and patients, as while treatment options are finite, the virus constantly adapts via complex mutation patterns to select for resistant strains under the pressure of drug treatment. The HIV protease is a crucial enzyme for viral maturation and has been a game changing drug target since the first application. Due to similarities in protease inhibitor designs, drug cross-resistance is not uncommon across ARVs of the same class. It is known that resistance against protease inhibitors is associated with a wider active site

SUBMITTER: Sheik Amamuddy O 

PROVIDER: S-EPMC6298995 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature