Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.

ABSTRACT: Macroautophagy (or autophagy) is a conserved cellular process in which cytoplasmic cargo is targeted for lysosomal degradation. Autophagy is crucial for the functional integrity of different subsets of T cells in various developmental stages. Since atherosclerosis is an inflammatory disease of the vessel wall which is partly characterized by T cell mediated autoimmunity, we investigated how advanced atherosclerotic lesions develop in mice with T cells that lack autophagy-related protein 7 (Atg7), a protein required for functional autophagy. Mice with a T cell-specific knock-out of Atg7 (Lck-Cre Atg7^f/f) had a diminished naïve CD4⁺ and CD8⁺ T cell compartment in the spleen and mediastinal lymph node as compared to littermate controls (Atg7^f/f). Lc

SUBMITTER: Amersfoort J 

PROVIDER: S-EPMC6299070 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature