Ontology highlight
ABSTRACT:
SUBMITTER: Scherr N
PROVIDER: S-EPMC6299076 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181218 1
Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc<sub>1</sub>:aa<sub>3</sub>. While the cytochrome bc<sub>1</sub>:aa<sub>3</sub> i ...[more]