Information-based autonomous reconfiguration in systems of interacting DNA nanostructures.

ABSTRACT: The dynamic interactions between complex molecular structures underlie a wide range of sophisticated behaviors in biological systems. In building artificial molecular machines out of DNA, an outstanding challenge is to develop mechanisms that can control the kinetics of interacting DNA nanostructures and that can compose the interactions together to carry out system-level functions. Here we show a mechanism of DNA tile displacement that follows the principles of toehold binding and branch migration similar to DNA strand displacement, but occurs at a larger scale between interacting DNA origami structures. Utilizing this mechanism, we show controlled reaction kinetics over five orders of magnitude and programmed cascades of reactions in multi-structure systems. Furthermore, we demonstrate t

SUBMITTER: Petersen P 

PROVIDER: S-EPMC6299139 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature