A Model for Human Islet Transplantation to Immunodeficient Streptozotocin-Induced Diabetic Mice.

ABSTRACT: Streptozotocin (STZ) is a cytotoxic glucose analogue that causes beta cell death and is widely used to induce experimental diabetes in rodents. The sensitivity of beta cells to STZ is species-specific and human beta cells are resistant to STZ. In experimental islet transplantation to rodents, STZ-diabetes must be induced before transplantation to avoid destruction of grafted islets by STZ. In human islet transplantation, injection of STZ before transplantation is inconvenient and costly, since human islet availability depends on organ donation and frail STZ-diabetic mice must be kept for unpredictable lapses of time until a human islet preparation is available. Based on the high resistance of human beta cells to STZ, we have tested a new model for STZ-diabetes induction in which STZ is inj

SUBMITTER: Estil Les E 

PROVIDER: S-EPMC6299193 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature