The Role of Galectins in Tumor Progression, Treatment and Prognosis of Gynecological Cancers.

ABSTRACT: Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell apoptosis, and immune cells, causing tumor invasion, progression, metastasis and angiogenesis. Somehow, galectins are also found to exert a protective effect on cancer in a tissue-dependent way. These glycans binding proteins have been shown to be involved in the regulation of different tumor suppressor genes and oncogenes with their possible roles in human cancers. Objective of the current review is to summarize the role of galectin-1, -3 -7, and -9 in tumorigenesis of gynec

SUBMITTER: Chetry M 

PROVIDER: S-EPMC6299382 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature