Radiomic signature of ¹⁸F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits.

ABSTRACT: We aimed to evaluate whether radiomic feature-based fluorine 18 (¹⁸F) fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging signatures allow prediction of gastric cancer (GC) survival and chemotherapy benefits. Methods: A total of 214 GC patients (training (n = 132) or validation (n = 82) cohort) were subjected to radiomic feature extraction (80 features). Radiomic features of patients in the training cohort were subjected to a LASSO cox analysis to predict disease-free survival (DFS) and overall survival (OS) and were validated in the validation cohort. A radiomics nomogram with the radiomic signature incorporated was constructed to demonstrate the incremental value of the radiomic signature to the TNM staging system for individualized survival estimation,

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC6299427 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature