The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection.

ABSTRACT:

Background

Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections.

Methods

This study examined the relationships between HLA-DQB1 alleles and HBV infection susceptibility among 256 HBV carriers and 433 healthy controls. Venous blood samples were subjected to DQB1 high-resolution typing and testing for interferon-gamma, interleukin-4 (IL-4), interleukin-10, and DQB1 mRNA expression. A meta-analysis was also performed using relevant case-control studies that evaluated the associations of HLA-DQB1 alleles with HBV infection and clearance.

Results

We found that HLA-DQB1*06:03 protected against HBV infection. Levels of IFN-γ and IL-4 were s

SUBMITTER: Ou G 

PROVIDER: S-EPMC6299522 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature