Gene expression profiles in genome instability-based classes of colorectal cancer.

ABSTRACT:

Background

Broad copy number aberrations (BCNAs) represent a common form of genome instability in colorectal cancer (CRC). CRCs show large variations in their level of aneuploidy: microsatellite-instable (MSI) tumors are known to have a near-diploid karyotype while microsatellite-stable (MSS) tumors show high level of chromosomal instability. However, MSS tumors have great heterogeneity in the number of BCNAs, with a minor percentage of samples showing an almost normal karyotype. In the present work we subdivided MSS CRCs according to a "BCNA score" and characterized their transcriptome profiles, considered as a proxy to their phenotypic features.

Methods

Microsatellite testing, genome-wide DNA copy number and whole-transcript expression analysis (HTA) were performed on 33 t

SUBMITTER: Barresi V 

PROVIDER: S-EPMC6299572 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature