Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients.

ABSTRACT:

Background

CD4⁺ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4⁺ regulatory T cells (Tregs) and CD4⁺ responder T cells (Tresps) causes flares of active disease in SLE patients. In this study, we aimed to find the role of aberrant Treg/Tresp cell differentiation for maintaining Treg/Tresp cell balance and Treg functionality.

Methods

To determine differences in the differentiation of Tregs/Tresps we calculated the percentages of CD45RA⁺CD31⁺ recent thymic emigrant (RTE) Tregs/Tresps and CD45RA⁺CD31^- mature naive (MN) Tregs/Tresps, as well as CD45RA^-CD31⁺ and CD45RA^-CD31^- memory Tregs/Tres

SUBMITTER: Schaier M 

PROVIDER: S-EPMC6299578 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature