Genetic association between the Pfk13 gene mutation and artemisinin resistance phenotype in Plasmodium falciparum isolates from Yunnan Province, China.

ABSTRACT:

Background

The problem of anti-malarial drug resistance is a long-term challenge faced by malaria control in Yunnan Province. Recently, the detection rates of chloroquine-resistant molecular markers (Plasmodium falciparum chloroquine resistant transporter, Pfcrt) and artemisinin-resistant molecular markers (P. falciparum kelch13 gene, ork13) were 85% and 35%, respectively. To understand the association of k13 gene mutation with artemisinin resistance in falciparum malaria cases, the difference in k13 gene differentiation between two populations and artemisinin resistance phenotype on falciparum malaria cases in Myanmar were analysed in this study.

Methods

This research involved all of falciparum malaria cases diagnosed continuously in Yunnan Province from 2013 to 2015 and so

SUBMITTER: Dong Y 

PROVIDER: S-EPMC6299582 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature