Dichotomy in redundant enhancers points to presence of initiators of gene regulation.

ABSTRACT:

Background

The regulatory landscape of a gene locus often consists of several functionally redundant enhancers establishing phenotypic robustness and evolutionary stability of its regulatory program. However, it is unclear what mechanisms are employed by redundant enhancers to cooperatively orchestrate gene expression.

Results

By comparing redundant enhancers to single enhancers (enhancers present in a single copy in a gene locus), we observed that the DNA sequence encryption differs between these two classes of enhancers, suggesting a difference in their regulatory mechanisms. Initiator enhancers, which are a subset of redundant enhancers and show similar sequence encryption to single enhancers, differ from the rest of redundant enhancers in their sequence encryption, evolu

SUBMITTER: Song W 

PROVIDER: S-EPMC6299655 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature