High-Efficiency, Matrix Interference-Free, General Applicable Probes for Bile Acids Extraction and Detection.

ABSTRACT: Although bile acids (BAs) have been suggested as important biomarkers for endocrine diseases, the identification and quantification of different BAs are still challenges due to their enormous species and wide range concentrations. Herein, a copolymer probe based on β-cyclodextrin (β-CD) is fabricated through a simple in-mold photopolymerization for the selective extraction of BAs. Through the unique stereochemical affinity between BAs and the cavity of β-CD, the custom probe shows superior enriching capacities to series BAs. Moreover, the outstanding extraction ability is proved to be consistent in various interfering conditions, including pH changing and the addition of complex matrix. Further comparison shows that the stereostructure of the nucleus of BAs plays a vital role during the fo

SUBMITTER: Huang S 

PROVIDER: S-EPMC6299822 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature