Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery.

ABSTRACT: BACKGROUND:Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-time in vivo tissue characterization. METHODS:Evaluating feasibility of the technology requires a setting in which measurements, imaging and pathology have the best possible correlation. For this purpose an optical biopsy needle was used that had integrated optical fibers at the tip of the needle. This approach enabled the best possible correlation between optical measurement volume and tissue histology. With this optical biopsy needle we acquired real-time DRS data of normal tissue and tumor tissue in 27 patients that underwent an ultrasound guided breast biopsy procedure. Fi

SUBMITTER: de Boer LL 

PROVIDER: S-EPMC6299954 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature