Locally dose-escalated radiotherapy may improve intracranial local control and overall survival among patients with glioblastoma.

ABSTRACT:

Background

The dismal overall survival (OS) prognosis of glioblastoma, even after trimodal therapy, can be attributed mainly to the frequent incidence of intracranial relapse (ICR), which tends to present as an in-field recurrence after a radiation dose of 60 Gray (Gy). In this study, molecular marker-based prognostic indices were used to compare the outcomes of radiation with a standard dose versus a moderate dose escalation.

Methods

This retrospective analysis included 156 patients treated between 2009 and 2016. All patients were medically fit for postoperative chemoradiotherapy. In the dose-escalation cohort a simultaneous integrated boost of up to 66 Gy (66 Gy RT) within small high-risk volumes was applied. All other patients received daily radiation to a total dose of 6

SUBMITTER: Zschaeck S 

PROVIDER: S-EPMC6299982 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature