Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study.

ABSTRACT:

Background

(Trans)-3,7-Dimethyl-2,6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic monoterpene alcohol with well-known anti-inflammatory and antimicrobial properties. Ge-OH is a non-toxic compound classified as Generally Recognized As Safe (GRAS) by the US Food and Drug Administration and the European Food Security Agency.

Methods

Ge-OH was orally administered at a maximum daily dose of 8 mg kg^(- 1) body weight for four weeks in a delayed release formulation capable of reaching the colon. Fecal microbiota and blood cytokines were analyzed before and after Ge-OH treatment, as well as IBS symptomatology by using Visual Analogue Scale (VAS-IBS).

Results

The results show that orally administered Ge-OH is a powerful modulator of the intestinal mi

SUBMITTER: Rizzello F 

PROVIDER: S-EPMC6299992 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature