Differential Effect of Plasma Estradiol on Subclinical Atherosclerosis Progression in Early vs Late Postmenopause.

ABSTRACT:

Context

The Early vs Late Intervention Trial with Estradiol showed that hormone therapy (HT) reduced progression of atherosclerosis when initiated in early but not in late postmenopause.

Objective

This posttrial analysis examined the association between plasma estradiol (E2) levels and atherosclerosis determined by rate of change in carotid artery intima-media thickness (CIMT) and tested whether this association is equally evident in early (<6 years) vs late (≥10 years) postmenopause.

Design

Randomized controlled trial stratified by time since menopause (ClinicalTrials.gov no. NCT00114517). Mixed-effects linear models tested the association of E2 levels with CIMT rate of change.

Setting

Los Angeles, California.

Participants

Healthy women in postmenopause

SUBMITTER: Sriprasert I 

PROVIDER: S-EPMC6300071 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature