In vivo protective effects of chlorogenic acid against triptolide-induced hepatotoxicity and its mechanism.

ABSTRACT:

Context

Triptolide (TP) has outstanding biological activities, but it induces toxicities, particular hepatotoxicity, severely limiting its clinical application. Chlorogenic acid (CGA) has prominently medicinal and nutritional values. However, until now, it is not known whether CGA could mitigate TP-induced hepatotoxicity.

Objective

This study explored the possible protection of CGA against TP-induced hepatotoxicity and its potential mechanisms, for the first time.

Material and methods

KM mice were treated orally with TP at a single dose of 1 mg/kg at 4 h after being treated with CGA (10, 20 and 40 mg/kg) for seven continuous days. Blood samples were collected at 24 h after TP administration for measurement of serum biomarkers, and hepatic tissues for analysis of poten

SUBMITTER: Wang JM 

PROVIDER: S-EPMC6300082 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature