Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study.

ABSTRACT: Red blood cell (RBC) traits provide insight into a wide range of physiological states and exhibit moderate to high heritability, making them excellent candidates for genetic studies to inform underlying biologic mechanisms. Previous RBC trait genome-wide association studies were performed primarily in European- or Asian-ancestry populations, missing opportunities to inform understanding of RBC genetic architecture in diverse populations and reduce intervals surrounding putative functional SNPs through fine-mapping. Here, we report the first fine-mapping of six correlated (Pearson's r range: |0.04 - 0.92|) RBC traits in up to 19,036 African Americans and 19,562 Hispanic/Latinos participants of the Population Architecture using Genomics and Epidemiology (PAGE) consortium. Trans-ethnic meta-a

SUBMITTER: Jo Hodonsky C 

PROVIDER: S-EPMC6300146 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature