Identification of molecular genetic contributants to canine cutaneous mast cell tumour metastasis by global gene expression analysis.

ABSTRACT: Cutaneous mast cell tumours are one of the most common canine cancers. Approximately 25% of the tumours metastasise. Activating c-kit mutations are present in about 20% of tumours, but metastases occur in the absence of mutations. Tumour metastasis is associated with significantly diminished survival in spite of adjuvant chemotherapy. Available prognostic tests do not reliably predict whether a tumour will metastasise. In this study we compared the global expression profiles of 20 primary cutaneous mast cell tumours that metastasised with those of 20 primary tumours that did not metastasise. The objective was to identify genes associated with mast cell tumour metastatic progression that may represent targets for therapeutic intervention and biomarkers for prediction of tumour metastasis. C

SUBMITTER: Bowlt Blacklock K 

PROVIDER: S-EPMC6300220 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature