Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.

ABSTRACT:

Background

Recent GWAS studies have identified more than 300 SNPs associated with variation in blood pressure. We investigated whether a genetic risk score constructed from these variants is associated with burden of coronary heart disease.

Methods

From 2010-2014, 4,809 individuals admitted to coronary angiography in Capital Region of Copenhagen were genotyped. We calculated hypertension GRS comprised of GWAS identified SNPs associated with blood pressure. We performed logistic regression analyses to estimate the risk of hypertension and prevalent CHD. We also assessed the severity of CHD associated with the GRS. The analyses were performed using GRS quartiles. We used the Inter99 cohort to validate our results and to investigate for possible pleiotropy for the GRS with othe

SUBMITTER: Lukacs Krogager M 

PROVIDER: S-EPMC6300273 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature