Distinct expression and prognostic value of members of the epidermal growth factor receptor family in ovarian cancer.

ABSTRACT:

Background

Increased aberrant expression or activation of the epidermal growth factor receptor (EGFR) family members has been reported in a wide range of cancers, and the EGFR family of tyrosine kinases has emerged as an important therapeutic target in malignancies. However, the expression patterns and exact roles of each distinct EGFR family member, which contribute to tumorigenesis and progression of ovarian cancer (OC), are yet to be elucidated.

Materials and methods

In the current study, we report the distinct expression and prognostic value of EGFR family members in patients with OC by analyzing a series of databases including ONCOMINE, Gene Expression Profiling Interactive Analysis, Kaplan-Meier plotter, cBioPortal, and Database for Annotati

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC6300368 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature