The potential effect of improved provision of rabies post-exposure prophylaxis in Gavi-eligible countries: a modelling study.

ABSTRACT:

Background

Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply.

Methods

We developed epidemiological and economic models to investigate the effect of an investment in post-exposure prophylaxis by Gavi, the Vaccine Alliance. We modelled post-exposure prophylaxis use according to the status quo, with improved access using WHO-recommended intradermal vaccination, with and without rabies immunoglobulin, and with and without dog vaccination. We took the health provi

SUBMITTER: WHO Rabies Modelling Consortium 

PROVIDER: S-EPMC6300480 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature