Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model.

ABSTRACT: The 2017 American College of Neuropychopharmacology (ACNP) conference hosted a Study Group on 4 December 2017, Establishing best practice guidelines to improve the rigor, reproducibility, and transparency of the maternal immune activation (MIA) animal model of neurodevelopmental abnormalities. The goals of this session were to (a) evaluate the current literature and establish a consensus on best practices to be implemented in MIA studies, (b) identify remaining research gaps warranting additional data collection and lend to the development of evidence-based best practice design, and (c) inform the MIA research community of these findings. During this session, there was a detailed discussion on the importance of validating immunogen doses and standardizing the general design (e.g., species,

SUBMITTER: Kentner AC 

PROVIDER: S-EPMC6300528 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature