High-dose ondansetron reduces activation of interoceptive and sensorimotor brain regions.

ABSTRACT: Several psychiatric disorders involve abnormalities of interoception and associated neural circuitry centered on the insula. The development of interventions modulating interoceptive circuits could lead to novel treatment approaches for these disorders. The 5-HT3 receptor antagonist ondansetron is a good candidate for the modulation of interoceptive circuits, as 5-HT3 receptors are located abundantly on sensory pathways and ondansetron has shown some clinical utility in disorders characterized by sensory and interoceptive abnormalities. The present study tested the ability of three different doses of ondansetron to engage neural regions involved in interoception to determine the drug's utility as a therapeutic agent to target circuit abnormalities in patients. Fifty-three healthy subjects

SUBMITTER: Stern ER 

PROVIDER: S-EPMC6300545 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature