H₂S, a Bacterial Defense Mechanism against the Host Immune Response.

ABSTRACT: The biological mediator hydrogen sulfide (H₂S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H₂S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections, Escherichia coli and Staphylococcus aureus Elevations in H₂S levels increased the resistance of both species to immune-mediated killing. Clearances of infections with wild-type and genetically H₂S-deficient E. coli and S. aureus were compared in vitro and in mouse models of abdominal sepsis and burn wound infection. Also, inhibitors

SUBMITTER: Toliver-Kinsky T 

PROVIDER: S-EPMC6300618 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature