Atg5 Supports Rickettsia australis Infection in Macrophages In Vitro and In Vivo.

ABSTRACT: Rickettsiae can cause life-threatening infections in humans. Macrophages are one of the initial targets for rickettsiae after inoculation by ticks. However, it remains poorly understood how rickettsiae remain free in macrophages prior to establishing their infection in microvascular endothelial cells. Here, we demonstrated that the concentration of Rickettsia australis was significantly greater in infected tissues of Atg5^flox/flox mice than in the counterparts of Atg5^flox/flox Lyz-Cre mice, in association with a reduced level of interleukin-1β (IL-1β) in serum. The greater concentration of R. australis in Atg5^flox/flox bone marrow-derived macrophages (BMMs) than in Atg5^flox/flox Lyz-Cre BMMs

SUBMITTER: Bechelli J 

PROVIDER: S-EPMC6300621 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature