Granzyme B Is an Essential Mediator in CD8⁺ T Cell Killing of <i>Theileria parva</i>-Infected Cells.

ABSTRACT: There is established evidence that cytotoxic CD8⁺ T cells are important mediators of immunity against the bovine intracellular protozoan parasite Theileria parva However, the mechanism by which the specific CD8⁺ T cells kill parasitized cells is not understood. Although the predominant pathway used by human and murine CD8⁺ T cells to kill pathogen-infected cells is granule exocytosis, involving the release of perforin and granzyme B, there is to date a lack of published information on the biological activities of bovine granzyme B. The present study set out to define the functional activities of bovine granzyme B and determine its role in mediating the killing of T. parva-parasitized cells. DNA constructs encoding functional and nonfunctional

SUBMITTER: Yang J 

PROVIDER: S-EPMC6300629 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature