Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide.

ABSTRACT: Acinetobacter baumannii is a Gram-negative opportunistic pathogen that causes diverse infections, including pneumonia, bacteremia, and wound infections. Due to multiple intrinsic and acquired antimicrobial-resistance mechanisms, A. baumannii isolates are commonly multidrug resistant, and infections are notoriously difficult to treat. The World Health Organization recently highlighted carbapenem-resistant A. baumannii as a "critical priority" for the development of new antimicrobials because of the risk to human health posed by this organism. Therefore, it is important to discover the mechanisms used by A. baumannii to survive stresses encountered during infection in order to identify new drug targets. In this study, by use of in vivo imaging, we identifie

SUBMITTER: Juttukonda LJ 

PROVIDER: S-EPMC6300632 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature