Brucella neotomae Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection Model.

ABSTRACT: Members of the genus Brucella are Gram-negative pathogens that cause chronic systemic infection in farm animals and zoonotic infection in humans. Study of the genus Brucella has been hindered by the need for biosafety level 3 select agent containment. Brucella neotomae, originally isolated from the desert pack rat, presented an opportunity to develop an alternative, non-select agent experimental model. Our prior in vitro work indicated that the cell biology and type IV secretion system (T4SS) dependence of B. neotomae intracellular replication were similar to observations for human-pathogenic select agent Brucella species. Therefore, here, we investigated the pathobiology of B. neotomae infection in the BALB/c mouse. During a sustained infec

SUBMITTER: Kang YS 

PROVIDER: S-EPMC6300638 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature