Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment.

ABSTRACT: According to the network-based neurodegeneration hypothesis, neurodegenerative diseases target specific large-scale neural networks, such as the default mode network, and may propagate along the structural and functional connections within and between these brain networks. Cognitive impairment no dementia (CIND) represents an early prodromal stage but few studies have examined brain topological changes within and between brain structural and functional networks. To this end, we studied the structural networks [diffusion magnetic resonance imaging (MRI)] and functional networks (task-free functional MRI) in CIND (61 mild, 56 moderate) and healthy older adults (97 controls). Structurally, compared with controls, moderate CIND had lower global efficiency, and lower nodal centrality and nodal

SUBMITTER: Wang J 

PROVIDER: S-EPMC6300727 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature