Genetic influence on serum 25-hydroxyvitamin D concentration in Korean men: a cross-sectional study.

ABSTRACT:

Background

Hypovitaminosis D is prevalent worldwide. It is more prevalent in Eastern Asia region, including Korea. In addition to various environmental factors that influence serum 25-hydroxyvitamin D (25(OH)D) concentration, genetic influence also plays a significant role based on studies estimating the heritability of 25(OH)D in non-Asian populations. The objective of this study was to determine the genetic influence on serum 25(OH)D concentration in Korean men using the twin and family data.

Methods

A total of 1126 Korean male adult twins and family members from the Healthy Twin Study with serum 25(OH)D measurement were included in this cross-sectional study. Intraclass correlation coefficients (ICCs) and heritability were calculated by mixed linear regression analysis an

SUBMITTER: Choi S 

PROVIDER: S-EPMC6300879 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature