Association of IL10 gene promoter polymorphisms with risks of gastric cancer and atrophic gastritis.

ABSTRACT:

Objective

To investigate the association between polymorphisms of the interleukin 10 ( IL10) gene and risk of gastric cancer (GC) and atrophic gastritis (AG).

Methods

This study enrolled patients with GC, patients with AG and healthy control subjects. Demographic data were collected and the IL10 gene -1082A/G, -819C/T and -592A/C polymorphisms were genotyped. An enzyme-linked immunosorbent assay was performed to detect Helicobacter pylori infection.

Results

The study enrolled 556 participants including 208 in the GC group, 116 in the AG group and 232 controls (CON group). In a recessive model of the IL10-819C/T polymorphism, a significantly decreased risk of GC was found compared with AG and non-cancer subjects, respectively (AG→GC: odds ratio OR 0.41; non-cancer→GC:

SUBMITTER: Liu S 

PROVIDER: S-EPMC6300941 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature