Randomized controlled trial of transcranial magnetic stimulation in pregnant women with major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) affects 10% of pregnancies. Because transcranial magnetic stimulation (TMS) is a nonmedication option, psychiatric patients who do not tolerate or prefer to avoid antidepressants are good candidates for TMS.

Method

In a randomized controlled trial of twenty-two women with MDD in the second or third trimester of pregnancy, subjects were randomized to active TMS (n=11) or sham TMS (n=11). This study took place at a single academic center. Subjects received 20 sessions of TMS to the right dorsolateral prefrontal cortex at 1 Hz as a single train of 900 pulses per session at 100% motor threshold. Estradiol and progesterone and were measured before session 1 and after session 20.

Results

Results demonstrated significantly decreased

SUBMITTER: Kim DR 

PROVIDER: S-EPMC6301099 | biostudies-literature | 2019 Jan - Feb

REPOSITORIES: biostudies-literature