Characterization of CD28^null T cells in idiopathic pulmonary fibrosis.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease, with unknown etiopathogenesis and suboptimal therapeutic options. Previous reports have shown that increased T-cell numbers and CD28^null phenotype is predictive of prognosis in IPF, suggesting that these cells might have a role in this disease. Flow cytometric analysis of explanted lung cellular suspensions showed a significant increase in CD8⁺ CD28^null T cells in IPF relative to normal lung explants. Transcriptomic analysis of CD3⁺ T cells isolated from IPF lung explants revealed a loss of CD28-transcript expression and elevation of pro-inflammatory cytokine expression in IPF relative to normal T cells. IPF lung explant-derived T cells (enriched with CD28^null T cells), bu

SUBMITTER: Habiel DM 

PROVIDER: S-EPMC6301115 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature