Genetic and Environmental Influences on Verbal Fluency in Middle Age: A Longitudinal Twin Study.

ABSTRACT: Mounting evidence suggests that measures of phonemic fluency and semantic fluency are differentially associated with other cognitive and health phenotypes, but few studies have examined their shared and unique variance, especially using genetically-informative designs. In this study, 1464 middle-aged twins completed six fluency subtests at up to two time-points (mean age 56 and 62 years). Confirmatory factor analyses supported a two-factor solution: a General Fluency latent factor explained variation in all six subtests and a Semantic-Specific factor accounted for additional variance in semantic subtests. Both factors were explained primarily by genetic influences at both waves (a² = 0.57-0.76). There was considerable stability of individual differences over 6 years (r = .90 for

SUBMITTER: Gustavson DE 

PROVIDER: S-EPMC6301139 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature