Impact of pre-stroke sulphonylurea and metformin use on mortality of intracerebral haemorrhage.

ABSTRACT:

Introduction

Few proven therapies for intracerebral haemorrhage exist. Preliminary observational evidence suggests that sulphonylurea and metformin may be protective in ischaemic stroke. We assessed the association of pre-intracerebral haemorrhage sulphonylurea and metformin use on outcome in diabetic patients.

Methods

We merged datasets from the consecutive single-centre Helsinki ICH Study, the intracerebral haemorrhage arm of the Virtual International Stroke Trials Archive (VISTA-ICH) and the Royal Melbourne Hospital ICH Study. Logistic regression adjusting for known predictors of intracerebral haemorrhage outcome (age, sex, baseline Glasgow Coma Scale, National Institutes of Health Stroke Scale, intracerebral haemorrhage volume, infratentorial location, intraventricular e

SUBMITTER: Wu TY 

PROVIDER: S-EPMC6301244 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature