Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite.

ABSTRACT: S-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O₂˙^- promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO^-). Since the production of O₂˙^- can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine.

SUBMITTER: Alhasan R 

PROVIDER: S-EPMC6301271 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature