Clinical characteristics and outcomes of primary sclerosing cholangitis and ulcerative colitis in Japanese patients.

ABSTRACT:

Background

In Western countries, most patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). The number of patients with UC in East Asia has increased markedly over the past two decades. However, current clinical features of PSC and of PSC associated with UC (PSC-UC) have not yet been clarified in East Asia, particularly in Japan. We aimed to reveal the clinical courses and associations with UC in Japanese patients with PSC from the mutual viewpoint of PSC and UC.

Methods

We retrospectively retrieved medical records of patients with PSC (69) and UC (1242) who were diagnosed at Chiba University Hospital between June 1991 and August 2017.

Results

In the present cohort, 37 patients had PSC-UC; the cumulative risks of PSC in patients w

SUBMITTER: Kumagai J 

PROVIDER: S-EPMC6301618 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature